Comparative cytotoxic study of silica materials functionalised with essential oil components in HepG2 cells

This work evaluated the cytotoxic effect of different EOCs-functionalised silica particle types. The in vitro toxicity eugenol and vanillin-immobilised SAS, MCM-41 microparticles nanoparticles was on HepG2 cells, compared to free EOCs pristine materials. results revealed that essential oil components bare had a mild cells. However, comparative study showed vanillin milder than equivalent concentrations immobilised particles, while differences cell viability between functionalised particles relied type analysed material. most materials were vanillin-functionalised micro with IC50 values 0.19 0.17 mg/mL, respectively, at 48 h exposure. Differences cytotoxicity may be attributed density functional their surface as result functionalisation reaction performance for physico-chemical properties demonstrated cationic nature increased hydrophobicity could responsible promoting cell-particle interactions enhancing behaviour.